JSFiddle - React, Tailwind, and code Playground

HTML

<img id="img" src="https://www.w3schools.com/jsref/smiley.gif" alt="Smiley" width="32" height="32">

JavaScript

var img = document.getElementById('img');

img.onmouseover = function() {
	changeIt = setInterval(function(){
    var red = Math.floor(Math.random() * 255);
    var green = Math.floor(Math.random() * 255);
    var blue = Math.floor(Math.random() * 255);
    img.style.backgroundColor="rgb("+red+","+green+","+blue+")";
  },25);
}

img.onmouseout = function() {
	this.style.backgroundColor="transparent";
  clearInterval(changeIt);
}