JSFiddle - React, Tailwind, and code Playground

HTML

<select id="billing:region_id" name="billing[region_id]">
    <option value="">Por favor, selecione o estado</option>
    <option data-sigla="AC" value="485">Acre</option>
    <option data-sigla="AL" value="486">Alagoas</option>
    <option data-sigla="CE" value="490">Ceará</option>
    <option data-sigla="DF" value="511">Distrito Federal</option>
    <option data-sigla="ES" value="491">Espírito Santo</option>
</select>

JavaScript

var dados = {
    uf: 'DF'
};

$('option').each(function() {
    $(this).attr('selected', this.dataset.sigla == dados.uf);
});