JSFiddle - React, Tailwind, and code Playground

HTML

<select data-placeholder="User auswählen ..." multiple class="chosen_multi" name="items[]" id='userSelect'>
<option value="1">111</option>
<option value="2" selected>222</option>
<option value="3" selected>333</option>
</select>
<button id="setBtn" type="button">
Set
</button>
<button  id="resetBtn"type="button">
Reset
</button>

CSS

select { width: 10em; }

JavaScript

$("#resetBtn").click(function() {
  $("#userSelect").val([]);
})
$("#setBtn").click(function() {
  $("#userSelect").val(['1', '2']);
})