JSFiddle - React, Tailwind, and code Playground
HTML
<div id="top1">
<a> <span id="s1" class="myclass">a</span></a>
<i><span id="s2" class="myclass">b</span></i>
</div>
<div id="top2">
<span id="s1" class="myclass-old">a</span>
<span id="s2" class="myclass">b</span>
</div>
CSS
.myclass-new{
background : #f00;
}
JavaScript
$('#top1 span').attr('class', 'myclass-new');