JSFiddle - React, Tailwind, and code Playground
HTML
<div id="usersec">
<TABLE style="TEXT-ALIGN: center; WIDTH: 279px; HEIGHT: 70px">
<TBODY>
<TR>
<TD style="FONT-FAMILY: Verdana" vAlign=center align=middle id="cellToChange">Talk to me</TD>
</TR></TBODY></TABLE>
</div>
JavaScript
var container = document.getElementById('usersec');
var td = container.querySelector('tr:first-child > td');
if(td){
td.innerHTML = "New Text!";
}