JSFiddle - React, Tailwind, and code Playground

HTML

<flex-container>
  <flex-item>
    <div></div>
    <div></div>
  </flex-item>
  <flex-item class="big"></flex-item>
  <flex-item>
    <div></div>
    <div></div>
  </flex-item>
</flex-container>

<br><hr><br>

<flex-container>
  <flex-item class="big"></flex-item>
  <flex-item>
    <div></div>
    <div></div>
  </flex-item>
  <flex-item>
    <div></div>
    <div></div>
  </flex-item>
</flex-container>

CSS

flex-container {
  display: flex;
}
flex-item {
  flex-grow: 1;
  height: 200px;
  margin: 0 5px;
  display: flex;
  flex-direction: column;
}
.big {
  flex: 0 0 40%;
  background-color: black;
}
div {
  flex-grow: 1;
  background-color: black;
}
div + div { margin-top: 10px; }