JSFiddle - React, Tailwind, and code Playground
HTML
<div id="block">
<a href="javascript:void(0)" onclick='alert(1)'>Реклама 1</a>
<iframe srcdoc="<a href='javascript:void(0)' onclick='alert(2)'>Реклама 2</a>"></iframe>
</div>JavaScript
document.querySelector('#block').addEventListener('click', e => {
e.stopImmediatePropagation();
e.preventDefault();
}, true);