JSFiddle - React, Tailwind, and code Playground

HTML

<div class="feed">
  <div class="post big"></div>
  <div class="post big">
    <div class="small"></div>
    <div class="small"></div>
  </div>
  <div class="post big">
    <div class="small"></div>
    <div class="small"></div>
  </div>
  <div class="post big"></div>

</div>

CSS

.feed {
  border:1px red solid;
  display:flex;
  height: 650px;
  flex-wrap:wrap;
  flex-direction:row;
  align-items: flex-start;
  flex-direction: column;
}
.big {
  width: 420px;
  height: 250px;
  background-color: #ccc;
  margin: 10px 10px 10px 10px;
  display: flex;
}
.small {
  width: 200px;
  height: 230px;
  background-color: #fff;
  margin: 10px;
}