Edit in JSFiddle

<p>Hello, world! 🌍</p>

<p>The screen reader will ignore the emoji in the above example.</p>
document.querySelector("p").innerHTML = document.querySelector("p").innerHTML.replace(/(?:[\u2700-\u27bf]|(?:\ud83c[\udde6-\uddff]){2}|[\ud800-\udbff][\udc00-\udfff]|[\u0023-\u0039]\ufe0f?\u20e3|\u3299|\u3297|\u303d|\u3030|\u24c2|\ud83c[\udd70-\udd71]|\ud83c[\udd7e-\udd7f]|\ud83c\udd8e|\ud83c[\udd91-\udd9a]|\ud83c[\udde6-\uddff]|[\ud83c[\ude01-\ude02]|\ud83c\ude1a|\ud83c\ude2f|[\ud83c[\ude32-\ude3a]|[\ud83c[\ude50-\ude51]|\u203c|\u2049|[\u25aa-\u25ab]|\u25b6|\u25c0|[\u25fb-\u25fe]|\u00a9|\u00ae|\u2122|\u2139|\ud83c\udc04|[\u2600-\u26FF]|\u2b05|\u2b06|\u2b07|\u2b1b|\u2b1c|\u2b50|\u2b55|\u231a|\u231b|\u2328|\u23cf|[\u23e9-\u23f3]|[\u23f8-\u23fa]|\ud83c\udccf|\u2934|\u2935|[\u2190-\u21ff])/g, `<span aria-hidden="true">$&</span>`);