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https://datatables.net/forums/discussion/72538/bug-responsive-searchpanes-layout-auto/p1?new=1

by Raidek

HTML

<link rel="stylesheet" type="text/css" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/5.0.1/css/bootstrap.min.css"/>
<link rel="stylesheet" type="text/css" href="https://cdn.datatables.net/1.11.5/css/dataTables.bootstrap5.min.css"/>
<link rel="stylesheet" type="text/css" href="https://cdn.datatables.net/searchpanes/2.0.0/css/searchPanes.bootstrap5.min.css"/>
<link rel="stylesheet" type="text/css" href="https://cdn.datatables.net/select/1.3.4/css/select.bootstrap5.min.css"/>
  
<script type="text/javascript" src="https://code.jquery.com/jquery-3.6.0.min.js"></script>
<script type="text/javascript" src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/5.0.1/js/bootstrap.bundle.min.js"></script>
<script type="text/javascript" src="https://cdn.datatables.net/1.11.5/js/jquery.dataTables.min.js"></script>
<script type="text/javascript" src="https://cdn.datatables.net/1.11.5/js/dataTables.bootstrap5.min.js"></script>
<script type="text/javascript" src="https://cdn.datatables.net/searchpanes/2.0.0/js/dataTables.searchPanes.min.js"></script>
<script type="text/javascript" src="https://cdn.datatables.net/searchpanes/2.0.0/js/searchPanes.bootstrap5.min.js"></script>
<script type="text/javascript" src="https://cdn.datatables.net/select/1.3.4/js/dataTables.select.min.js"></script>
<table id="example" class="table table-striped table-bordered table-hover dt-responsive nowrap" style="width:100%">
        <thead>
            <tr>
                <th>Name</th>
                <th>Position</th>
                <th>Office</th>
                <th>Age</th>
                <th>Start date</th>
                <th>Salary</th>
            </tr>
        </thead>
        <tbody>
            <tr>
                <td>Tiger Nixon</td>
                <td>System Architect</td>
                <td>Edinburgh</td>
                <td>61</td>
                <td>2011/04/25</td>
                <td>$320,800</td>
            </tr>
            <tr>
                <td>Garrett...

JavaScript

$(document).ready(function() {
  $('#example').DataTable({
    searchPanes: {
      layout: 'columns-6',
      cascadePanes: true,
      viewTotal: true,
      //layout: 'auto'
    },
    dom: 'Plfrtip',
    columnDefs: [{
      searchPanes: {
        show: true
      },
      targets: [0, 1, 2, 3, 4, 5]
    }]
  });
});

// EXAMPLE BOOTSTRAP https://datatables.net/extensions/searchpanes/examples/styling/bootstrap5.html
/*$(document).ready(function() {
  var table = $('#example').DataTable({
    searchPanes: {
    cascadePanes: true,
      viewTotal: true,
      //layout: 'columns-6',
      layout: 'auto'
    },
    dom: 'Plfrtip',
    columnDefs: [{
      searchPanes: {
        show: true
      },
      targets: [0, 1, 2, 3, 4, 5]
    }]
  });
  table.searchPanes.container().prependTo(table.table().container());
  table.searchPanes.resizePanes();
});*/