JSFiddle - React, Tailwind, and code Playground

HTML

<form action="upload.php" method="POST" enctype="multipart/form-data">
	<input type="file" name="file" id="file">
	<button name="submit" type="submit">upload</button>
</form>

JavaScript

document.querySelector('button[name="submit"]').addEventListener('click', event => {
  event.target.setAttribute('disabled', true)
})