JSFiddle - React, Tailwind, and code Playground

HTML

<div class="container">
    <div class="box-1"></div>
    <div class="smaller-container">
        <div class="box-2"></div>
        <div class="box-3"></div>
        <div class="box-5"></div>
    </div>
    <div class="box-4"></div>
    <div class="box-5"></div>
</div>

CSS

* {
    box-sizing: border-box;
    margin: 0;
    padding: 0;
}

html,
body {
    height: 100%;
}

body {
    max-width: 1366px;
    margin: auto;
    width: 100%;
}

.container {
    display: flex;
    flex-wrap: wrap;
    flex-direction: row;
}

.box-1 {
    order: 1;
    background-color: red;
    height: 150px;
    width: 50%;
}

.smaller-container {
    display: flex;
    flex-wrap: wrap;
    flex-direction: row;
    width: 50%;
    order: 2;
}

.box-2 {
    order: 3;
    background-color: blue;
    height: 75px;
    width: 100%;
}

.box-3 {
    order: 4;
    background-color: green;
    height: 75px;
    width: 100%;
}

.smaller-container > .box5 {
    display: none;
}

.container > .box-5 {
    order: 6;
    background-color: orange;
    height: 150px;
    width: 100%;
}

@media screen and (max-width: 1000px) {
    .box-2 {
        height: 50px;
    }
    .box-3 {
        height: 50px;
    }
    .container > .box-4 {
        order: 6;
        background-color: purple;
        height: 150px;
        width: 100%;
    }
    .smaller-container > .box-5 {
        display: block;
        height: 50px;
        background-color: orange;
        width: 100%;
        order: 6;
    }
    .container > .box-5 {
        display: none;
    }
}