Edit in JSFiddle

<div class="container">
  <div class="block"></div>
  <div class="block"></div>
  <div class="block"></div>
  <div class="block"></div>
  <div class="block"></div>
</div>
.container {
  display: grid;
  grid-template-columns: repeat(6, 40px);
  grid-auto-rows: 80px;
  grid-gap: 10px;
}

.block {
  background-color: red;
  grid-column-end: span 2;
}

.block:nth-last-child(-n+2) {
  grid-column-start: 2
}
.block:nth-last-child(-n+1) {
  grid-column-start: 4
}