JSFiddle - React, Tailwind, and code Playground

HTML

<span id="myLabel">
    <span class="comment">You're great!</span><span class="separator">, </span><span class="comment">You're mediocre!</span><span class="separator">, </span><span class="comment">You suck!</span>
</span>

JavaScript

$(function() {
    $('.comment').click(function() {
        //decide which comma to remove
        if ($(this).prevAll('.comment').size() == 0) {
            //this is the first comment, remove the next comma and this comment
            $(this).next('.separator').remove().end().remove();
        } else {
            //this is not the first comment, remove the previous comma and this comment
            $(this).prev('.separator').remove().end().remove();
        }
    });
});