JSFiddle - React, Tailwind, and code Playground

HTML

<div class="owl-item cloned">Element</div>
<div class="owl-item cloned">Element</div>
<div class="owl-item cloned">Element</div>
<div class="owl-item active">Element</div>
<div class="owl-item active">Element</div>
<div class="owl-item active">This What I want to target</div>
<div class="owl-item cloned">Element</div>
<div class="owl-item cloned">Element</div>

CSS

.owl-item {
    background-color: green;
    color:#FFF;
    margin: 10px 50px;
    padding: 10px
}
.owl-item.active:last-of-type {
    background-color: red;
}