JSFiddle - React, Tailwind, and code Playground

HTML

<div class="wrapper">
    <div>text</div>
    <div></div>
    <div>text</div>
    <div>text</div>
    <div></div>
</div>

CSS

div:not(.wrapper) {background-color:#ff0000; padding:10px; margin:5px}

JavaScript

var patt= new RegExp("<div></div>");
                     
document.querySelector('.wrapper').innerHTML.replace(patt,'')