Vertical flexbox

Header sized to content, with fixed footer, and content region that fills the remaining space.

HTML

<section class="main">
  <header>
    header: sized to content
      <br/>(but is it really?)
  </header>
  <div class="columns">
  <div class="column left">
  left
  </div>
  <div class="column center">
    main content: fills remaining space<br>
    x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>
    x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>
    x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>
    x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>
    x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>
    x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>
    x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>
    x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>
    x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>
    x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>
    x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>
    x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>
    x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>
    x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>
    x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>
    x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>
    x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>
    x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>
    x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>
    x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>
    x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>
    x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>
    x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>
    x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>
    x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>x<br>
  </div>
  
  <div class="column right">
  right
  </div>
    </div>

  <footer>
    footer: fixed height in px
  </footer>
</section>

CSS

body {
  margin: 0px;
}
.main {
  display: flex;
  flex-flow: column;
  height: 100vh;
}
header {
  background: tomato;
;
}
.columns {
  flex: 1;
  display: flex;
  flex-flow: row;
  background: gold;
  overflow: auto;
}
.column {
  float: left;
  width: 25%;
}
.center {
  width: 50%;
  overflow-y: auto;
  background: white;
}
footer {
  background: lightgreen;
  min-height: 60px;
}