JSFiddle - React, Tailwind, and code Playground

HTML

<ul id="list3">
    <li>A</li><li>B</li><li>C</li><li>D</li>
</ul>

CSS

.clicked {
    background: gold;
}

JavaScript

$(function() {   
    $("#list3 li").click(function (e) {
        // PLACED INSIDE CONDITIONAL
        if (!e.ctrlKey) {
            $("#list3 li").removeClass('clicked');
        }
        $(this).toggleClass('clicked');  // LINE MODIFIED
    });
});