JSFiddle - React, Tailwind, and code Playground

HTML

<div id="div_to_change">
    This is the text
    <br>
    to be changed
    <div id="div_that_shouldnt_change">
       text that should not change
    </div>
    <div id="div_that_shouldnt_change2">
       text that should not change
    </div>
</div>

JavaScript

$("div").contents().filter(function(){ return this.nodeType == 3; }).first().replaceWith("changed text");