JSFiddle - React, Tailwind, and code Playground

HTML

<select id="CC" multiple="multiple">
    <option value="1">Valor 1</option>   
    <option value="2">Valor 2</option>
    <option value="3">Valor 3</option>
    <option value="4">Valor 4</option>
</select>

JavaScript

$(document).ready(function(){
    $(document).on("mousedown", '#CC option', function (e) {
        debugger;
        this.selected = !this.selected;
        e.preventDefault();
    }); 
});