JSFiddle - React, Tailwind, and code Playground

HTML

<div class='ExternalClassF5C37A3BE1FB40A782DF583ABBB86FBC'>hel,lqwo:;</div>

JavaScript

$('.ExternalClassF5C37A3BE1FB40A782DF583ABBB86FBC').text(function (_,txt) {
    return txt.replace(':', '').replace(';', '').replace(',', '');
});