JSFiddle - React, Tailwind, and code Playground

HTML

<div><strong><em>Please select me!</em></strong></div>

<div><strong><p><em>Please don't select me!</em></p></strong></div>

<div><p><em>Please don't select me!</em></p></div>

CSS

div :not(p)>em {
  color: red;
  font-weight: bold;
}