JSFiddle - React, Tailwind, and code Playground

HTML

<body ng-cloak>
  <div id="header">Header</div>
  <div id="main">
    <div id="left" class="panel">
      <div class="largeChild"></div>
      <div class="largeChild"></div>
      <div class="largeChild"></div>
    </div>
    <div id="center" class="panel">
      <div class="largeChild"></div>
      <div class="largeChild"></div>
      <div class="largeChild"></div>
    </div>
    <div id="right" class="panel">
      <div class="largeChild"></div>
      <div class="largeChild"></div>
      <div class="largeChild"></div>
    </div>
  </div>
  <div id="footer">Footer</div>
</body>

CSS

* {
    box-sizing: border-box;
  }

  html, body {
    margin: 0;
    height: 100vh;
    width: 100vw;
    display: flex;
    display: -webkit-flex;
    flex-direction: column;
    -webkit-flex-direction: column;
    background-color: blue;
  }

  #header, #footer {
    flex: 0 0 100px;
    -webkit-flex: 0 0 100px;
    background-color: blue;
  }

  #main {
    background-color: yellow;
    flex: 1 0 0px; /** Don't set parent of component to auto */
    -webkit-flex: 1 0 0px; /** Don't set parent of component to auto */
    display: flex;
    display: -webkit-flex;
    flex-direction: row;
    -webkit-flex-direction: row;
  }

  .panel {
    display: flex;
    display: -webkit-flex;
    flex-direction: column;
    -webkit-flex-direction: column;
    flex: 1 0 auto;
    -webkit-flex: 1 0 auto;
    overflow: auto;
  }
  #left.panel {
    background-color: red;
    flex: 0 0 200px;
    -webkit-flex: 0 0 200px;
  }
  #right.panel {
    background-color: gray;
    flex: 0 0 200px;
    -webkit-flex: 0 0 200px;
  }

  .largeChild {
    margin: 5px;
    padding: 5px;
    min-height: 500px;
    min-width: 10px;
    background-color: green;
  }