Edit in JSFiddle

var counter = 0;
document.id('clickme').addEvent('click', function(event){
    event.stop();
    this.highlight();

    if (counter++ == 1) this.removeEvents('click');
});

<a href="#" id="clickme">You can click me only twice</a>

#clickme {
    display: block;
    padding: 20px;
    font-size: 2em;
}