JSFiddle - React, Tailwind, and code Playground

HTML

<div id="one">
       <div class="first"></div>
       "Hi I am text"
       <div class="second"></div>
       <div class="third"></div>
</div>

JavaScript

$('#one').contents().filter(function() {
    return this.nodeType == 3
}).each(function(){
    this.textContent = this.textContent.replace('Hi I am text','Hi I am replace');
});