JSFiddle - React, Tailwind, and code Playground

HTML

<header>Some nav stuff here</header>

<h1>This is the heading</h1>

<div id="theCalcDiv">This blocks needs to have a CSS calc() height of 100% - the height of the other elements.</div>

CSS

html,body {
    background: blue;
    height:100%;
    padding:0;
    margin:0;
}
header {
    background: red;
    height: 20px;
    width:100%
}
h1 {
    font-size:1.2em;
    margin:0;
    padding:0;
    height: 30px;
    font-weight: bold;
    background:yellow
}
#theCalcDiv {
    background:green;
    height: -moz-calc(100% - (20px + 30px));
    height: -webkit-calc(100% - (20px + 30px));
    height: calc(100% - (20px + 30px));
    display:block
}