JSFiddle - React, Tailwind, and code Playground

HTML

<select id="CentroCusto_new" multiple="multiple">
    <option selected>Option 1</option>
    <option >Option 2</option>
    <option>Option 3</option>
    <option>Option 4</option>
</select>

JavaScript

$(document).ready(function() {
    $('select#CentroCusto_new option').on('mousedown', function (e) {
        this.selected = !this.selected;
        e.preventDefault();
    });
});