Edit in JSFiddle

Result
JavaScript
HTML
CSS

$(document).ready(function () {
                $("#myDiv").hover(function () {
                    $(this).removeClass("class1 class2");
                });
            });

<html>
        <head>
        <title>removeClass</title>
        </head>
        <body>
        <span id="myDiv" class="class1 class2">
        Hover Me
        </span>
        <br />
        <input type="button" value="Reset" onclick="location.reload()" />
        </body>
        </html>

 .class1
        {
        margin-left:100px;
        width:200px;
        height:200px;
        display:block;
        }
        .class2
        {
        background-color:Aqua;
        }