JSFiddle - React, Tailwind, and code Playground

HTML

<div id="bar">
  <div onmouseover="document.bgColor='gray'" onmouseout="document.bgColor='white'" style="border:1px solid black;">
   <span onclick="document.getElementById('bar').innerHTML = ''">Remove me</span>
  </div>
</div>

JavaScript

var div = document.getElementsByTagName('div')[0];
div.addEventListener('DOMNodeRemoved', function(e){
    document.bgColor='white'
});