JSFiddle - React, Tailwind, and code Playground

HTML

<div id="_1">
     1
    <div id="_2" class="nolist">2</div>
  </div>
  <div id="_3">3
    <div id="_4">4
      <div id="_5">5</div>
      <div id="_6">6</div>
    </div>
  </div>

CSS

div {
    margin: 10px;
}

div:last-child:not(.nolist) { 
    border: 1px solid red; 
}