JSFiddle - React, Tailwind, and code Playground

HTML

<link rel="stylesheet" href="http://ivaynberg.github.io/select2/select2-3.3.2/select2.css">
<script src="http://ivaynberg.github.io/select2/select2-3.3.2/select2.js"></script>
<select id="sel" data-placeholder="This is my placeholder">
    <option></option>
    <option value="a">hello</option>
    <option value="b">all</option>
    <option value="c">stack</option>
    <option value="c">overflow</option>
</select>
<br>
<button id="pres">Disable and clear</button>
<button id="ena">Enable</button>

CSS

#sel {
    margin: 20px;
}

JavaScript

$(document).ready(function () {
    $("#sel").select2();

    $("#pres").click(function () {
      
        $('.select2-container > a > span').text('This is my placeholder');
        $("#sel").empty().select2("disable");;
       });
    
    $("#ena").click(function () {
        $("#sel").select2("enable");
    });
});