JSFiddle - React, Tailwind, and code Playground

HTML

<script src="http://ajax.microsoft.com/ajax/jquery.validate/1.7/jquery.validate.js"></script>
<link rel="stylesheet" href="http://ajax.googleapis.com/ajax/libs/jqueryui/1.8.2/themes/ui-lightness/jquery-ui.css">
<div id="typehead">
    The Birdsong Collective and Micropress was founded in April 2008 with four goals in mind: to foster sustained collaboration among artists, musicians and writers in the form of an ongoing workshop; to continually encourage each other to produce creative work; to host free, public events where members can showcase works in progress; and to circulate members’ creative endeavors in a low-cost, easy to reproduce, and high-frequency format. Birdsong members share commitments to social movements of feminism, anti-racism, queer positivity, class-consciousness, and DIY cultural production. These commitments inform our creative work in many ways, ranging from the concrete to the theoretical to the experimental.
</div>

CSS

.newClass {
    left: 0px;
    top: -1px;
    color: red;
    position:relative;
    -webkit-transform: rotate(-5deg); 
    -moz-transform: rotate(-5deg);    
}

JavaScript

function randomLetter(cased){
    // case = true for uppercase, false for lowercase
    var base = (cased) ? 65 : 97;
    // convert HTML escape code into a letter
    var rand = $('<span>&#' + parseInt(base+(Math.random()*26),10) + ';</span>');
    return rand.text();
}

$(document).ready(function(){
    var ltr = randomLetter(false);
    var reg = new RegExp( ltr, 'g');
    $('#typehead').html(function(i,html){
     return html.replace(reg, '<span class="newClass">' + ltr + '</span>');
    });
})