JSFiddle - React, Tailwind, and code Playground

HTML

<div class="content-box">
    <h1>Title Here</h1>
    Here is some text I need to target
</div>

CSS

.content-box > span {
    color: red;
}

JavaScript

$('.content-box').contents().filter(function () {
    return this.nodeType === 3;
}).wrap('<span></span>');