JSFiddle - React, Tailwind, and code Playground
HTML
<span id='myspan'>SPAN
<div>TEXT</div>
<a href="">LINK</a>
</span>
JavaScript
$('#myspan').children().html('');
<span id='myspan'>SPAN
<div>TEXT</div>
<a href="">LINK</a>
</span>
$('#myspan').children().html('');